On November 29, 1962, Byrne was born in Fort Wayne, Indiana. He was raised in Hanover, New Hampshire, after being born in Woodstock, Vermont.

Between 1989 and 1991, Byrne held positions with Blackhawk Investment Co. and Elissar, Inc. in addition to holding an adjunct professorship at Stanford University.

Byrne was hospitalized for most of his 20s due to testicular cancer, which he contracted shortly after graduating from college and overcame.

Patrick Byrne Net Worth