Mari has a limited calf, even though Tierney has muscle mass tightness and has been remaining out as a precaution by Arteta.
In their place, Ainsley Maitland-Niles commences at left-again, with David Luiz coming in at centre-back alongside Rob Keeping.
Despite that defensive setback, Gabriel Magalhaes returns right after a period of self-isolation and is on the bench, when Thomas Partey is again from a thigh injuries and will take his place amongst the substitutes.
Arsenal XI: Leno, Bellerin, Holding, Luiz, Maitland-Niles, Ceballos, Xhaka, Saka, Smith-Rowe, Aubameyang, Lacazette
Subs: Gabriel, Willian, Runarsson, Cedric, Partey, Pepe, Chambers, Willock, Nketiah